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Diazepam se ne sme primenjivati kao monoterapija u terapiji depresije i anksioznosti udružene sa depresijom, jer kod ove grupe pacijenata može uzrokovati pojavu suicida.Predloženi mehanizam interakcije je kompetitivno vezivanje teofilina za adenozinske receptore u mozgu. Na taj način onemogućava se farmakodinamsko dejstvo diazepama, dolazi do

Whole details of the person experiments are provided in the 'Qualities of provided research' and 'Traits of excluded research' sections.Codeine shouldn't be employed for agony aid in small children and adolescents just after removing in their tonsils or adenoids because of Obstructive Snooze Apnoea Syndrome (rest disruption on account of respirator

Hepatic Insufficiency Decreases in clearance and protein binding, and will increase in quantity of distribution and half-existence are already noted in clients with cirrhosis. In these patients, a two- to five-fold increase in suggest 50 %-daily life has long been documented. Delayed elimination has also been documented with the Energetic metabolit